Anchored HTML File of EIDs

	WEB-based GEne SeT AnaLysis Toolkit

	*Translating gene lists into biological insights...*

User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:

C: the number of reference genes in the category
O: the number of genes in the gene set and also in the category
E: the expected number in the category
R: ratio of enrichment
rawP: p value from hypergeometric test
adjP: p value adjusted by the multiple test adjustment

Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway Name:Neuroactive ligand-receptor interaction ID:04080
C=272; O=4; E=0.37; R=10.75; rawP=0.0005; adjP=0.0013
Index	UserID	Value	Gene Symbol	Gene Name	EntrezGene	Ensembl
1	ENSG00000114812	NA	VIPR1	vasoactive intestinal peptide receptor 1	7433	ENSG00000114812
2	ENSG00000121764	NA	HCRTR1	hypocretin (orexin) receptor 1	3061	ENSG00000121764
3	ENSG00000126895	NA	AVPR2	arginine vasopressin receptor 2	554	ENSG00000126895
4	ENSG00000094755	NA	GABRP	gamma-aminobutyric acid (GABA) A receptor, pi	2568	ENSG00000094755

Database:KEGG pathway Name:Proximal tubule bicarbonate reclamation ID:04964
C=23; O=2; E=0.03; R=63.56; rawP=0.0005; adjP=0.0013
Index	UserID	Value	Gene Symbol	Gene Name	EntrezGene	Ensembl
1	ENSG00000167434	NA	CA4	carbonic anhydrase IV	762	ENSG00000167434
2	ENSG00000240583	NA	AQP1	aquaporin 1 (Colton blood group)	358	ENSG00000240583

Database:KEGG pathway Name:Hypertrophic cardiomyopathy (HCM) ID:05410
C=83; O=2; E=0.11; R=17.61; rawP=0.0058; adjP=0.0097
Index	UserID	Value	Gene Symbol	Gene Name	EntrezGene	Ensembl
1	ENSG00000159640	NA	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	1636	ENSG00000159640
2	ENSG00000007402	NA	CACNA2D2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	9254	ENSG00000007402

Database:KEGG pathway Name:MAPK signaling pathway ID:04010
C=268; O=2; E=0.37; R=5.45; rawP=0.0522; adjP=0.0653
Index	UserID	Value	Gene Symbol	Gene Name	EntrezGene	Ensembl
1	ENSG00000168067	NA	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	5871	ENSG00000168067
2	ENSG00000007402	NA	CACNA2D2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	9254	ENSG00000007402

Database:KEGG pathway Name:Metabolic pathways ID:01100
C=1130; O=2; E=1.55; R=1.29; rawP=0.4599; adjP=0.4599
Index	UserID	Value	Gene Symbol	Gene Name	EntrezGene	Ensembl
1	ENSG00000143772	NA	ITPKB	inositol-trisphosphate 3-kinase B	3707	ENSG00000143772
2	ENSG00000074416	NA	MGLL	monoglyceride lipase	11343	ENSG00000074416

WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).